4. MOLECULAR NEUROBIOLOGY

Aim
The course aims at providing knowledge of concepts of Molecular Neurobiology in the context of investigating and understanding gene function in the nervous system.  

Contents

• general introduction to molecular biological principles
• various quantification methods (e.g. quantitative PCR, Western blotting)
• screening techniques (hybridization, micro arrays, SAGE, deep sequencing)
• structure-function research (mutagenesis, 3D structure analysis)
• genetic intervention studies (viral vectors, transgenesis, RNAi, peptide-mimetics)
• protein-protein interaction (immunoprecipitation, yeast two hybrid)
• proteomics technology (protein identification and quantification, determining phosphorylation with MS)
• cellomics technology (cellular high-content screening)
• genome projects and the use of electronic databases (Entrez-based)
• various examples from current research involving the above topics

Difference between PhD- and master-course
The PhD course includes content of various BSc and MSc courses. It is distinct as it uses selected recent topics in Molecular Neurobiology and includes examples from current research. Also, the course includes some experimental work.
This course should NOT be followed by PhD students with a profound knowledge in the Molecular Neuroscience field (see contents).

Duration of the course / ECTS
56 hrs / 2,0 ECTS

Format
Lectures and practicals

Maximum number of participants
16

Organizers
Prof.dr. A.B. Smit (NCA-CNCR)
Prof.dr. J. Verhaagen (NIN)

Year / dates next course
tba

Program of last course
See downloadable file

Registration through
Els Borghols ( els.borghols@cncr.vu.nl )